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Malaria vaccine ingredients

There are currently no commercially available vaccines for malaria. However, several promising candidates are in development, each with its own unique ingredients: 1. RTS,S/AS01 (Mosquirix): This is the only malaria vaccine that has received regulatory approval. It is a recombinant protein vaccine that targets the circumsporozoite protein (CSP) on the surface of Plasmodium falciparum sporozoites, the stage of the parasite transmitted by mosquitoes. The vaccineand#39;s ingredients include:

  • Recombinant CSP:andnbsp;This is the main active ingredient of the vaccine.andnbsp;It is a genetically modified protein that is similar to the CSP protein found on sporozoites.
  • AS01 adjuvant:andnbsp;This is a proprietary adjuvant system that helps to boost the immune response to the vaccine.andnbsp;It contains 3-O-desacyl-4and#39;-monophosphoryl lipid A (MPL) and aluminum hydroxide.
  • Other ingredients:andnbsp;These include water,andnbsp;sodium chloride,andnbsp;histidine,andnbsp;polysorbate 80,andnbsp;and sodium phosphate.
2. PfSPZ Vaccine: This is a candidate vaccine developed by Sanaria using radiation-attenuated sporozoites. These are live, weakened sporozoites that can stimulate the immune system to produce a protective response against malaria. The vaccineand#39;s ingredients include:
  • Plasmodium falciparum sporozoites:andnbsp;These are the live,andnbsp;weakened parasites that form the basis of the vaccine.
  • Cryopreservant:andnbsp;This is a substance that helps to preserve the sporozoites during storage and transport.
  • Buffer solution:andnbsp;This helps to maintain the proper pH and osmotic pressure for the sporozoites.
3. R21/Matrix-M: This is a candidate vaccine that uses a combination of a viral vector and a protein adjuvant. The viral vector delivers genetic material that instructs the bodyand#39;s cells to produce the CSP protein. The protein adjuvant helps to boost the immune response to the vaccine. The vaccineand#39;s ingredients include:
  • Recombinant adenovirus type 26 (Ad26):andnbsp;This is the viral vector that delivers the genetic material for the CSP protein.
  • Matrix-M adjuvant:andnbsp;This is a protein adjuvant that helps to boost the immune response to the vaccine.
  • Other ingredients:andnbsp;These include water,andnbsp;sodium chloride,andnbsp;histidine,andnbsp;polysorbate 80,andnbsp;and sodium phosphate.
4. ME-TRAP: This is a candidate vaccine that targets the Merozoite TRAP protein, which is essential for the parasiteand#39;s invasion of red blood cells. The vaccineand#39;s ingredients include:
  • Recombinant Merozoite TRAP protein:andnbsp;This is the main active ingredient of the vaccine.andnbsp;It is a genetically modified protein that is similar to the TRAP protein found on merozoites.
  • Adjuvant:andnbsp;The specific adjuvant used in this vaccine is still under development.
  • Other ingredients:andnbsp;These may include water,andnbsp;sodium chloride,andnbsp;histidine,andnbsp;polysorbate 80,andnbsp;and sodium phosphate.
It is important to note that these are just a few examples of the many different malaria vaccine candidates currently in development. Each vaccine has its own unique ingredients and formulation, and the specific ingredients may change as the vaccines continue to be developed and tested. Please note that this information is for educational purposes only and should not be construed as medical advice. Please consult with a healthcare professional for more information about malaria vaccines. Sources:
  1. naturalthyroidsolutions.com/ingredients